Panos Tzortzinis studied free drawing in the workshop of the painter George Vogiatzis and engraving in the workshop of the engraver Aria Komianou.
Experiences of all kinds of difficulties of everyday life will shape the deep human point of view through which he sees his subjects in his painting, which he designed very early. In 1979 he presented for the first time his paintings at the Cultural Center of the Municipality of Egaleo. This was followed by solo exhibitions of his works in the galleries "Zygos" in 1981, "Yakinthos" in 1986, "Antinor" in 1990 and 1992, but also his participations in group exhibitions (1982, "Zygos" 1987-1989, "Antinor"). In 1985 the Agricultural Bank of Greece published its diary with reproductions of his works and in 1991 the Medicheck Medical Research Center his own again with images of his works. He has adorned with his works books by Greek writers and album covers by Greek composers.